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Barbiturates can induce hepatic microsomal enzymes resulting in increased metabolism and lessened anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); patients stabilized on anticoagulant therapy may perhaps call for dosage adjustments if barbiturates are added to or withdrawn from their dosage program

pentobarbital will lower the extent or effect of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of siponimod having a drug that causes moderate CYP2C9 as well as a average or potent CYP3A4 inducer is not really advisable.

pentobarbital will lower the extent or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will reduce the level or impact of fludrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will reduce the extent or result of losartan by impacting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Mysterious.

pentobarbital will minimize the extent or influence of vardenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will decrease the extent or influence of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Powerful or moderate CYP3A4 inducers noticeably minimize guanfacine plasma concentrations and elimination half-lifetime.

Contraindicated (one)pentobarbital will lower the extent or influence of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will minimize the extent or result of tinidazole by impacting hepatic/intestinal enzyme CYP3A4 website metabolism. Use Caution/Watch.

Observe Intently (1)pentobarbital will raise the stage or result of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lower the level or impact of vincristine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.

pentobarbital will decrease the extent or result of dexamethasone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will reduce the level or influence of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.

pentobarbital will lessen the level or outcome of estrogens conjugated synthetic by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.